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By incorporating both host characteristics and viral genetics, the tool offers a more accurate method for anticipating zoonotic threats and guiding surveillance efforts than previous models. “Nearly three-quarters of emerging viruses that infect humans come from animals. If we can better predict which species pose the greatest risk, we can take proactive measures to prevent pandemics,” said Stephanie Seifert, assistant professor at Washington State University.

By harnessing AI to anticipate and prevent disease spread, this breakthrough highlights the transformative intersection of biotechnology and AI driven by Washington state.

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The achievement, documented today in a set of research papers published by the Nature family of journals, is being compared to the Apollo moon shots that were launched more than 50 years ago, and to the drafts of the human genome that were released more than 20 years ago.

Scientists from Seattle’s Allen Institute played a key role in the $100 million effort known as the Machine Intelligence from Cortical Networks program, or MICrONS. More than 150 researchers worked together through MICrONS to create a detailed 3D map of a cubic millimeter taken from a mouse’s brain — and figure out how the 200,000 brain cells in a speck the size of a coarse grain of sand work together.

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The team combined the RFdiffusion model, an open-source AI program for generating proteins that was previously developed by Baker’s lab, with a newer tool called PLACER that helped them identify the most promising de novo enzyme candidates. “Now we can make these enzymes tailored to any reaction of interest, theoretically,” said Anna Lauko, a recent Ph.D. graduate from Baker’s lab. “It’s sort of flipped the way that we would do enzyme design.”

This breakthrough revolutionizes enzyme design, unlocking a wide range of applications and underscoring the region’s leadership in protein design.

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Tissue-resident memory cells provide a local first line of defense against re-infection and call for “backup” from other immune cells and are also critical for maintaining peace in a tissue exposed to many outside pathogens.

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